Location and properties of ligand binding sites provide important information to uncover protein functions and to direct structure-based drug design approaches.However, as binding site detection depends on the three-dimensional (3D) structural data of proteins, functional analysis based on protein ligand binding sites is formidable for proteins wit
The mechanical structure and the control of the locomotion of bipedal humanoid is an important and challenging domain of research in bipedal robots.Accurate models of the kinematics and dynamics of the robot are essential to achieve bipedal locomotion.Toe-foot walking produces a more natural and faster walking speed and it is even possible to perfo
Barth syndrome (BTHS) is an X-linked recessive genetic disorder due to mutations in the Tafazzin (TAFAZZIN) gene that lead to cardiac and skeletal muscle mitochondrial dysfunction.Previous studies in humans with BTHS demonstrate that the defects in muscle mitochondrial oxidative metabolism result in an enhanced reliance on anaerobic metabolism duri
Antimicrobial resistance happens when microorganisms mutates in manners that render the drugs like antibacterial, antiviral, Coat Rack antiparasitic and antifungal, ineffective.The normal mutation process is encouraged by the improper use of antibiotics.Mutations leading to quinolone resistance occur in a highly conserved region of the quinolone re